Risk of schizophrenia increased with increasing paternal age

Advancing paternal age and the risk of schizophrenia.

BACKGROUND A major source of new mutations in humans is the male germ line, with mutation rates monotonically increasing as father's age at conception advances, possibly because of accumulating replication errors in spermatogonial cell lines. METHOD We investigated whether the risk of schizophrenia was associated with advancing paternal age in a population-based birth cohort of 87 907 individ...

Is paternal age associated with an increased risk of low birthweight, preterm delivery, and multiple birth?

OBJECTIVE To determine if paternal age elevates the risk of low birthweight (< 2500g, LBW), preterm birth (< 37 weeks gestation), and multiple gestation among mothers whose age does not predict an elevated risk. DESIGN/METHODS Population data on birth outcome, maternal age and paternal age was obtained from Alberta Health and Wellness for all births 1990-1996. RESULTS Among women aged 25 to...

Risk of autism and increasing maternal and paternal age in a large north American population.

Previous studies are inconsistent regarding whether there are independent effects of maternal and paternal age on the risk of autism. Different biologic mechanisms are suggested by maternal and paternal age effects. The study population included all California singletons born in 1989-2002 (n = 7,550,026). Children with autism (n = 23,311) were identified through the California Department of Dev...

Paternal age at birth of first child and risk of schizophrenia.

OBJECTIVE Greater paternal age is associated with increased risk of schizophrenia, and it has been hypothesized that de novo mutations in paternal germ cells are responsible for this association. An alternative hypothesis is that selection into late fatherhood accompanies a predisposition to schizophrenia. However, direct evidence of either hypothesis is lacking. If de novo mutations are respon...

Advancing Paternal Age and Risk of Autism